Top 10 Peptide Moisturizers for Plump, Radiant Skin

Ginny in Beauty & Fitness Aug 13 • 24 min read

Peptides are short chains of amino acids that help maintain the skin's structure, boosting collagen production and improving elasticity.

When combined with other hydrating and nourishing ingredients, they make moisturizers more effective in promoting plump, radiant skin. Here’s a comprehensive guide to the ten best peptide moisturizers that are worth considering for your skincare routine.

1. Medik8 Total Moisture Daily Facial Cream - $45

Key Ingredients: Prebiotic peptides, hyaluronic acid, ceramides
Why We Love It: Medik8 Total Moisture Daily Facial Cream is designed to enhance your skin’s natural bounce and resilience. The prebiotic peptides in this formula help to strengthen the skin barrier while promoting a balanced skin microbiome. Hyaluronic acid adds an intense layer of hydration, making the skin appear more plump and supple. Ceramides work in tandem with these ingredients to lock in moisture and protect the skin from environmental stressors. The lightweight texture is perfect for daily use, keeping your skin soft and nourished without feeling heavy.
Size: 1.6 fl oz

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2. Rhode Peptide Glazing Fluid - $30

Key Ingredients: Niacinamide, hyaluronic acid, peptides
Why We Love It: The Rhode Peptide Glazing Fluid is a quick-absorbing gel moisturizer that brings an instant glow to your skin. Its combination of peptides and niacinamide works to smooth and firm the skin while evening out the complexion. The addition of hyaluronic acid ensures that your skin remains hydrated throughout the day. This moisturizer is particularly loved for its ability to create a dewy finish without leaving any greasy residue, making it an ideal choice for those with oily or combination skin.
Size: 1.7 fl oz

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3. AziMD Skincare Restore - $95

Key Ingredients: Niacinamide, peptides, hyaluronic acid, resveratrol
Why We Love It: AziMD Skincare Restore is an antioxidant-rich formula that goes beyond just moisturizing. The inclusion of resveratrol, a potent antioxidant, helps protect the skin from free radicals and environmental damage. Niacinamide and peptides work synergistically to improve skin texture, reduce the appearance of fine lines, and enhance overall radiance. Hyaluronic acid deeply hydrates the skin, leaving it plump and youthful-looking. Although on the pricier side, its multi-functional benefits make it a worthwhile investment for long-term skin health.
Size: 1.7 fl oz

4. Lancôme Rénergie H.P.N 300-Peptide Face Cream - $145

Key Ingredients: Hyaluronic acid, peptides, niacinamide
Why We Love It: Lancôme’s Rénergie H.P.N 300-Peptide Face Cream is a luxurious option that targets multiple signs of aging. With 300 types of peptides, this cream focuses on improving skin firmness and elasticity, giving your face a lifted, youthful appearance. The addition of niacinamide helps to brighten the skin and reduce the appearance of pores, while hyaluronic acid provides long-lasting hydration. This cream is particularly effective for those looking to address fine lines, wrinkles, and loss of firmness, making it a favorite among those with mature skin.
Size: 2.5 fl oz

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5. Peter Thomas Roth Peptide Skinjection Moisture Infusion Refillable Cream - $52

Key Ingredients: Peptides, squalane, hyaluronic acid
Why We Love It: Peter Thomas Roth’s Peptide Skinjection Moisture Infusion Refillable Cream is designed for deep hydration and skin barrier repair. The peptides in this formula stimulate collagen production, helping to reduce the appearance of fine lines and wrinkles. Squalane, a lightweight oil, provides additional hydration without clogging pores, making it suitable for all skin types. Hyaluronic acid further enhances the skin’s moisture retention, leaving it plump and radiant. The refillable packaging is also a plus for those who are environmentally conscious.
Size: 1.7 oz

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6. Shani Darden Skin Care Hydration Peptide Cream - $60

Key Ingredients: Peptides, squalane
Why We Love It: Shani Darden’s Hydration Peptide Cream is an oil-free moisturizer that focuses on delivering hydration without adding extra shine. The combination of peptides and squalane works to nourish the skin while maintaining a matte finish, making it ideal for those with oily or combination skin. The peptides help to improve skin texture and firmness, while squalane ensures that your skin stays soft and moisturized throughout the day. This cream is particularly praised for its lightweight, non-greasy formula that absorbs quickly and provides long-lasting hydration.
Size: 2.5 oz

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7. Skinfix Barrier+ Strengthening and Moisturizing Triple Lipid-Peptide Cream - $54

Key Ingredients: Lipids, peptides, vitamins
Why We Love It: Skinfix Barrier+ Triple Lipid-Peptide Cream is designed to restore and strengthen the skin’s moisture barrier. The blend of lipids and peptides in this formula works to repair and protect the skin from dryness and irritation. Vitamins add an extra layer of nourishment, helping to improve skin texture and tone. This cream is especially beneficial for those with sensitive or compromised skin, as it provides deep hydration and barrier support without irritating. Its rich texture is ideal for nighttime use or during colder months when the skin needs extra care.
Size: 1.7 oz

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8. Drunk Elephant Protini Polypeptide Firming Refillable Moisturizer - $60

Key Ingredients: Peptides, antioxidants
Why We Love It: Drunk Elephant’s Protini Polypeptide Firming Moisturizer is a favorite for its ability to visibly improve skin firmness and texture over time. The powerful blend of peptides and antioxidants works to repair and rejuvenate the skin, making it appear more youthful and radiant. The moisturizer has a lightweight, gel-cream texture that absorbs quickly, leaving the skin feeling hydrated and plump without any greasiness. The refillable packaging is a bonus, making it a more sustainable option for your skincare routine.
Size: 1.69 oz

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9. Eminence Organic Skin Care Arctic Berry Peptide Radiance Cream - $98

Key Ingredients: Arctic berries, peptides
Why We Love It: Eminence Organic Skin Care’s Arctic Berry Peptide Radiance Cream is a luxurious organic option that harnesses the power of arctic berries and peptides to boost skin radiance. The antioxidant-rich arctic berries help to protect the skin from environmental damage, while peptides work to improve skin texture and firmness. This cream is known for its ability to brighten and even out the complexion, making it a great choice for those looking to enhance their skin’s natural glow. The rich, creamy texture provides ample hydration, leaving the skin soft and luminous.
Size: 2 oz

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10. Youth To The People Polypeptide-121 Future Cream - $68

Key Ingredients: Peptides, plant protein, ceramides
Why We Love It: Youth To The People’s Polypeptide-121 Future Cream is a cutting-edge moisturizer that combines peptides with plant protein and ceramides to improve skin elasticity and resilience. The peptides in this formula help to boost collagen production, while plant proteins provide additional nourishment and support for the skin. Ceramides work to strengthen the skin barrier, locking in moisture and protecting against environmental aggressors. This cream is loved for its ability to improve skin firmness and texture, making it a great choice for those looking to prevent or address early signs of aging.
Size: 2 fl oz

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Final Thoughts

Choosing the right peptide moisturizer can make a significant difference in the appearance and health of your skin. Whether you’re looking for something lightweight and quick-absorbing, like the Rhode Peptide Glazing Fluid, or a more luxurious option like the Lancôme Rénergie H.P.N 300-Peptide Face Cream, there’s something on this list for everyone.

Incorporating one of these peptide-packed moisturizers into your skincare routine will help you achieve plump, radiant skin that feels as good as it looks.